Home Health Migraine complications: Might nerve stimulation assist? – Harvard Well being Weblog

Migraine complications: Might nerve stimulation assist? – Harvard Well being Weblog

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Are you one of many 20 million to 40 million folks within the US struggling with migraine complications? In that case, right here’s information value noting: The FDA has simply permitted an over-the-counter nerve stimulation machine that delivers gentle electrical shocks to the brow as a strategy to stop or deal with migraine complications.

This may appear to be an unlikely strategy to deal with migraines, so how did we get right here? And what’s the proof that it really works? Is that this a recreation changer? Hype? Or a therapy that falls someplace in between?

Our altering understanding of what causes migraines

Blood vessels all through the physique, together with these close to the mind, slender (constrict) and open up (dilate) commonly, all through the day. That’s regular, and it varies relying on the state of affairs. Sleep, physique temperature, bodily exercise, and plenty of different components have an effect on this exercise of blood vessels. Not way back, standard knowledge held that migraines had been as a consequence of an exaggeration of this regular constriction and dilation of blood vessels. Consultants thought {that a} set off — like sure meals, stress, or a bunch of different components — made blood vessels supplying pain-sensitive components of the mind all of a sudden constrict for a short time after which dilate, earlier than returning to regular. We all know that related blood vessel adjustments happen in different situations comparable to Raynaud’s disease, so this was an interesting principle to clarify migraine signs.

If migraines had been as a consequence of exaggerated blood vessel constriction and dilation in some folks, that would clarify why migraines are so widespread, non permanent, and never related to any everlasting damage to the mind or different components of the physique. Nevertheless, this principle is now thought-about mistaken.

The present principle of migraine

Present proof (as described in this review) means that migraine complications start with an irregular activation of cells within the nervous system that spreads throughout the mind. This results in irritation close to pain-sensitive components of the mind, the discharge of chemical messengers, and adjustments within the sensitivity of nerves that carry ache indicators. Among the many nerves concerned are branches of the trigeminal nerve. This nerve gives sensation to areas of the face, and controls muscular tissues that enable us to chunk or chew. It’s additionally linked to the pain-sensitive lining of the mind.

This evolving understanding of potential causes of migraine complications has led to therapies that focus much less on blood vessel adjustments and extra on methods to dam chemical messengers concerned in ache indicators. Triptan medicines, together with sumatriptan (Imitrex and others) and rizatriptan (Maxalt), are good examples.

What about nerve stimulation for migraines?

Lately, research have demonstrated {that electrical} stimulation of branches of the trigeminal nerve over the brow can deal with migraine complications and even stop them. One such machine, the Cefaly Dual, has been accessible by prescription to forestall migraine complications since 2014. It was simply cleared as an over-the-counter machine to forestall and deal with migraine complications. Clearance differs from FDA approval for effectiveness and security for medication and lifesaving expertise like defibrillators; it permits medical machine makers to market a product as a result of the FDA considers it protected and just like different legally marketed merchandise.

The proof supporting nerve stimulation to forestall or deal with migraine consists of the next:

  • A study published in 2013 enrolled 67 folks with migraines and in contrast electrical stimulation to sham stimulation for 20 minutes every day as a strategy to stop complications. Over three months, fewer complications and a decreased want for migraine treatment had been noticed amongst these getting the true therapy. Enchancment by no less than 50% was famous in 38% of examine topics, however in solely 12% of the sham group.
  • In a 2013 survey of greater than 2,300 folks utilizing electrical stimulation for 20 minutes every day for 2 months to forestall migraine, simply over half reported satisfaction with the machine and a willingness to purchase it.
  • A 2019 study randomly assigned 106 folks with an energetic migraine headache to obtain electrical stimulation over the brow or a sham therapy (minimal electrical stimulation) for one hour. These receiving therapy reported ache discount of almost 60% whereas these within the sham group had solely 30% ache discount.

What about downsides?

None of those research reported severe unintended effects associated to electrical stimulation. Whereas a tingling sensation on the web site of stimulation was widespread, few perceived it as painful or bothersome sufficient to cease therapy.

Price is a consideration. The machine’s maker at present lists its normal worth as $499, and states that it’s not coated by medical insurance. It does include a 60-day money-back assure, which might assist customers determine if it’s well worth the worth.

Lastly, there’s the time dedication. To stop migraines, customers are suggested to use the machine for 20 minutes every day. For therapy of acute headache, a 60-minute therapy is really useful.

The underside line

This therapy has been round since no less than 2014 and is actually no remedy. So, electrical stimulation for migraine can hardly be thought-about a recreation changer for many migraine victims. But it surely appears to me it’s not empty hype both. There may be affordable proof that it’s protected and no less than considerably efficient.

The current motion by the FDA to make the Cefaly Twin accessible with out a prescription ought to make it extra accessible. And, by any measure, a modestly efficient, drug-free strategy to deal with migraine is a constructive improvement. Hopefully, future research of this machine will make clear who’s probably to profit by utilizing it. However we’d like even higher choices. Advances in our understanding of how migraines develop and ongoing analysis ought to present them.

Comply with me on Twitter @RobShmerling

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